Discovering a centuries-old religious painting that shouldn't exist, an introverted art restorer slowly succumbs to the evil temptations of the mystical canvas, even as otherworldly forces strive to prevent her from revealing the artwork's unholy secret.
Beatrice Matheson works as an art restorer at a major museum, burying herself in her career while ignoring her own artistic gifts. As she begins cleaning the museum's latest acquisition, she discovers that underneath the visible landscape on the canvas' surface hides an unbelievable treasure: the last known painting by one of the most reclusive Renaissance Masters of all time.
But as she uncovers this lost masterpiece piece by minuscule piece, people who have come in contact with the painting begin dying under horrific circumstances, each one overcome with visions from beyond.
Fearing the worst, Beatrice enlists the help of a nerdy colleague and her brother, an ordained Catholic priest, to unravel the truth behind the painting's origins. Soon it becomes clear that this is no mere image on canvas, but a mystical barrier between this world... and the world below.
As the barriers between reality and the unknown collapse around her, can Beatrice find the strength to resist the painting's temptations, and save the world from destruction?